Mg-8 may contribute to the binding to factors VIIa and X



Model of factor IXa. The epidermal growth factor (green) and serine protease (yellow) domains of factor IXa (42) are shown connected to the IXGD1–46 structure (white), using factor VIIa structure (17) as a reference model. The bound Mg2+ and Ca2+ ions are drawn as orange and blue spheres, respectively. D-Phe-Pro-Arg-chloromethylketone, which is bound to the active site, is shown as a red stick model. The phospholipid membrane surface is shown by a yellow line. Hydrophobic residues (yellow), basic residues (purple) and Mg2+ ion (Mg-1) of GD1–46 are possible candidates for membrane binding.

Additional Resources
For additional information, see: Hemophilia